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Most preclinical studies have relied on HK-2 cells (human proximal tubular epithelial cells) and generic animal models, but the cell type-specific contribution to CIN-related ferroptosis is severely understudied

As such, we may struggle to absorb the vitamin B12 from food

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Interestingly, the closest relatives of many mtDNA-modifying enzymes, such as mtDNA polymerase, are bacteriophage proteins [94], suggesting that an infection of the mitochondrial ancestor contributed to the development of mtDNA maintenance machinery

Here is what we know, what we do not know, and where the gaps are