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paratuberculosis (MAP), primarily invades the distal ileum via M cells, persists in macrophages through intracellular immune evasion, and results in granuloma formation, villus atrophy, mucosal thickening, and barrier dysfunction, ultimately leading to chronic diarrhea, weight loss, and reduced milk production 1,77,78

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This breakthrough study provided the first evidence that stimulation of adult neurogenesis might be regulated through transient DNA demethylation of extrinsic factors in the hippocampal neurogenic niche

10.3390/ijms26020631 26 FormaggioN.RubinM

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