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Nevertheless, both RMT as well as adsorptive transcytosis are ideal for macromolecular transport [159]

Rev Assoc Med Bras 59(5):429434 Acknowledgements All authors have read and approved the final manuscript

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FIGURE 7 7 Discussion 7.1 Limits of preclinical models and translational relevance While a growing body of preclinical evidence supports the therapeutic potential of redox-targeted antioxidants and stem cellderived EVs in mitigating oxidative stress and restoring ovarian function, significant translational hurdles remain before these strategies can be applied clinically in women