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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

Ki=5.9 nM) allowing for extended and specific microglial elimination, preceding and during pathology development

You eat less, your insulin works better, and your body gradually draws on fat stores

doi:10.1093/fampra/cml008

Common lab protocols involve reconstitution in bacteriostatic water and subcutaneous injection in animal models using calibrated syringes to achieve precise dosing