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Fourthly, the severity of the IVD degeneration possibly influences the therapeutic effect of injected cells and/or growth factors, since degenerated CLCs may have lost their chondrogenic potential and the effect of injected cells and/or growth factors may differ between early and severely degenerated IVDs [90]

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Immunotherapies belong to the field of research in which the development of specific inhibitors or regulators presents the most significant advances in therapy development

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