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The first trial was an investigator-initiated, randomized controlled study designed to evaluate the safety and efficacy of single-dose DPSC therapy, conducted at Beijing Stomatological Hospital from May 22, 2020, to February 16, 2023 (Ethical code: CMUSH-IRB-KJ-PJ-2019-14)

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2 (Buffo et al., 2022) could survive and grow at pressures associated with the ice-ocean interface of Europa (10 MPa to 30 MPa)

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