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Both 13 C-labeled purine intermediate (IMP, AMP and GMP) and pyrimidine intermediate (UMP and CMP) levels were reduced in OGT-deficient H1299 cells and A549 cells (Fig

Using starting compositions with compounds rather than single elements is another strategy

At concentrations lower than those of DON, JHU395 has been found to decrease the growth and increase the apoptosis of high-MYC medulloblastoma cell lines, thereby prolonging the survival of treated animals (100)

Dysregulation and epigenetic reprogramming of NRF2 signaling axis promote acquisition of cisplatin resistance and metastasis in head and neck squamous cell carcinoma