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The clinical presentation varies depending on the pattern of injuryhepatocellular, cholestatic, or mixed

Autoantibodies and hypergammaglobulinemia can be detected in the serum [252]

(PubMed) Sesso HD, Buring JE, Christen WG, et al

Systemic Inflammatory Response Shock-like Reaction A recent (2025) case report described a patient who developed full-blown systemic inflammatory response syndrome (SIRS) after a high-dose, unregulated glutathione infusion for cosmetic skin-lightening

In the same context, the previous publication reported the involvement of Nrf2 in MTX-induced intestinal injury (Katturajan and Evan Prince 2023)