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We also propose that minimal criteria prompting genetic testing should be typical cEDS scars (at more than 2 sites) plus either generalized skin hyperextensibility (at least 3 of the currently defined areas and according to their cut-off values) and/or gJHM (BS 5), and/or 3 of the currently defined minor criteria, to which orthopedic issues may be added

Between now and then, the researchers estimate, up to 1.9 million people in the US will die due to smoke-related health issues

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Therefore, quitting smoking is particularly important for this group since smoking is the single largest contributor to their 10-20 year reduced life expectancy