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It can also be utilized as a step-down approach from other treatment options

Pain and distress can alter the behavior, physiology and immunology of animals, leading to variations in experimental results that may affect the reliability of studies 3

Glutathione is integral in this oxidative balance, as it protects against dangerous oxidative species clamoring to break through the cells defenses and is responsible for the renewal of other antioxidant agents

Topical application directly supports collagen and elastin production within the skin

Thus, in deploying APAP as a therapeutic option, one must account for both age-dependent differences in the PK/PD of APAP and the inter-patient variability within the pediatric population itself