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and (2) the diverse nonmotor symptoms (sleep disturbances, olfactory dysfunction, mood disorders, and cognitive decline) are linked to widespread syn pathology in limbic and cortical regions [19, 20, 21, 22, 23]

Since then, its metabolic role and significance in tumors have gradually been clarified (Fig

We propose that NADH-dependent glutamate dehydrogenase activity is favoured over NADPH production to meet the immediate energy requirements of the starved wild-type cells

Interestingly, when the gdh2 / gdh2 mutant utilised glucose as the sole carbon source (MM medium), most of the intracellular metabolites were found at lower concentrations than in the wild-type strain except for cysteine, malonate, nicotinate, 9-heptadecenoate, and 2-phosphoenolpyruvate