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Data of panels g,h,i are mean values standard deviation of three independent replicates

Up to respectively 70 and 40 M, AQ or DEAQ did not significantly activate any of the tested stress response pathways, which is consistent with the limited onset of cytotoxicity by these compounds ( Figure 2 )

doi: 10.1038/s41522-025-00646-5 221 YamamotoE

After the plasma membrane carrier-mediated GSH release from the cell, GSH becomes accessible to the active site of - glutamyl transpeptidase, which catalyzes the breakdown of the GSH - glutamyl bond forming two fractions: The -glutamyl fraction and the cysteinyl-glycine by transferring the -glutamyl fraction to an amino acid acceptor, forming -glutamyl-amino acid

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