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In clinical and in vivo studies, one can assess the effect of switching from cigarette smoking to cMRTP use on exposure responses by measuring biomarkers indicative of these mechanisms

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Decreased blood circulation Tobacco smoke contains chemicals that damage the small blood vessels in the body and decrease blood flow, including to the small blood vessels that supply the scalp with oxygen and nutrients (known as microcirculation) (Leone, 2013)

As technology develops, many applications have been enhanced to help smokers use e-cigs, intending to cut off nicotine slowly off their system

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