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In: Adam MP, Feldman J, Mirzaa GM, et al, eds

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Typically those with MTHFR polymorphisms (C677T or A1298C variants reduce methylenetetrahydrofolate reductase activity by 3070%), chronic alcohol use (depletes SAMe and impairs methionine adenosyltransferase), or vegan diets without B12 supplementation

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According to one hypothesis, that the tumor cells evoke a host response characterized by a proliferation of fibroblasts, the collagen production is of fibroblastic origin