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They should not, however, be used as a safe alternative to tobacco use

Palusiska M, Barabasz A, Kozak K, Papierniak A, Maliska K, Antosiewicz DM (2020) Zn/Cd status-dependent accumulation of Zn and Cd in root parts in tobacco is accompanied by specific expression of ZIP genes

In consultation with the study physician, research staff may switch participants to a lower nicotine concentration e-cigarette (3% instead of 5%) if necessary, in response to adverse events

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The condition can occur at any age, but is more often found in older patients