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Seleno-glutathione peroxidase mimic ebselen (PZ51)-protected endothelial and vascular system of spontaneous hypertensive rats (SHRsp) prone to stroke during pregnancy chronic hypertension [80]

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Moreover, since eukaryotes segregate the TCA cycle within the mitochondria while RNR is exclusively cytosolic [86], it is unlikely that the eukaryotic TCA cycle could be similarly modified to directly support DNA precursor production