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373 The pharmacological targeting of key molecules within this signaling pathway may provide new therapeutic avenues for combating immune aging and related diseases caused by HSC senescence

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It is frequently classified in scientific literature as a stable gastric pentadecapeptide, originally derived from a protein found in human gastric juice

This synergy is the basis of the modified Kligman formula, a combination of hydroquinone, tretinoin and a mild corticosteroid that is approved by the FDA for hyperpigmentation