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However, the reduced IGFBP binding comes with a significant pharmacokinetic trade-off: IGF-1 DES has an extremely short plasma half-life of only 20-30 minutes compared to the 12-15 hour half-life of endogenous IGF-1 in its IGFBP-bound state

These studies have also shown that dietary restriction simultaneously targets many of the molecular pathways that are targeted individually by anticancer drugs

Deng J, Zhao L, Zhang N-Y, Karrow NA, Krumm CS, Qi D-S, et al

Crdenas A, Rifas-Shiman SL, Agha G, Hivert M, Litonjua AA, DeMeo DL, Lin X, Amarasiriwardena C, Oken E, Gillman MW, Baccarelli A (2017) Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood