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As research on ferroptosis deepens and expands, more potential therapeutic targets have been discovered that can regulate ferroptosis based on the classical ferroptosis pathway

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The Cellular Redox System The cellular redox state refers to the balance between oxidation and reduction reactions (Calabrese et al., 2017

For example, the combination of curcumin and resveratrol inhibits NF-B activity by targeting IGF-1R signaling, ultimately leading to apoptosis and cell cycle arrest in natural colon cancer cells, suggesting that IGF-1R may be an anticancer approach (116)

Liao M, Peng L