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Also, people who have had surgery on their intestines, like weight loss surgery, or have diseases that affect the gut, like Crohns disease or celiac disease, are also at risk of not getting enough vitamin B12

Some protocols incorporate topical application to specific areas of concern alongside injectable administration for localized plus systemic benefits

The MIC nutrients are included for roles in methylation and hepatic lipid handling, while B12 (cobalamin) supports red-blood-cell formation and one-carbon metabolism

References Food and Drug Administration

Other studies showed that people with intestinal diseases, like inflammatory bowel disease (IBD), need extra vitamin B