glutathione and apoptosis Role of in Cancer: From Mechanisms to Therapies A critical role of glutathione

While in vitro equilibrations between redox couples such as roGFP2 and GSH/GSSG require minutes or even hours to reach a thermodynamic endpoint (G = 0), enzyme-catalyzed thiol-disulfide exchange reactions usually occur very rapidly and either maintain or reach a steady state (G 0) 7,31,32,60,63,67,78,79

INTRODUCTION Glutathione, the tripeptide -glutamyl-cysteinyl-glycine, plays a key role in detoxification and redox buffering processes in the cell (Noctor and Foyer, 1998)

At present, there are four kinds of western medicines used clinically to treat RA: nonsteroidal anti-inflammatory drugs, glucocorticoids, anti-rheumatic drugs and biological agents

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Glutathione is a naturally occurring antioxidant in the body, essential for neutralizing free radicals, detoxifying the liver, and bolstering the immune system