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This increased permeability allows lipopolysaccharides (LPS), food antigens, and microbial byproducts (PAMPs) to translocate into circulation, triggering systemic immune activation and placing further burden on mast cells 18

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Chinese medicine, which involves a mixture of different types and measurements of TCM combinations, is one of the main modalities used in TCM to correct imbalances in the internal environment of patients

The accumulation of these toxic lipids due to GPx4 deficiency could lead to damage to neuronal cell structure and subsequent cell death [7]

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