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The main metabolite, [ 3 H]proline (M1), accounted for 4.96% (female) and 3.93% (male) of the bile samples (Figure 5C)

It encompasses the structural and functional aspects of the cellular surroundings, but also the presence of metabolites such as glucose, amino acids and lipids within the TME, as well as environmental factors such as hypoxia and acidity (81)

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In vitro experiments demonstrated that resveratrol activates the SIRT1/Nrf2-ARE antioxidant pathway, thereby inhibiting the aberrant proliferation of RA-FLSs and inducing a significant increase in apoptosis