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Including heart attack, stroke and chronic obstructive pulmonary disease (COPD)

In addition to High-dose intravenous acetylcholine severe vasodilation and a profound drop in blood pressure, the high concentration of acetylcholine directly stimulates M2 muscarinic receptors in the sinoatrial (SA) node of the heart (Brown & Eccles, 1934)

With that said, there is still research that needs to be done to give you a definitive answer

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