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Simultaneously, they significantly influence immune cell function, thereby creating an immunosuppressive environment that further enhances drug resistance ( Furthermore, immune cells in the tumor microenvironment can potentially influence drug metabolism and elimination by releasing specific cytokines and chemical substances, thereby exacerbating drug resistance mechanisms ( Cancer stem cells (CSCs) are a population of tumor cells with self-renewal and differentiation potential

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(2015) in BioMed Research International demonstrated that GHK-Cu, at concentrations of 0.01, 1, and 100 nM, significantly increased collagen and elastin synthesis in human dermal fibroblasts

In addition, COF-618-Cu displays superior CAT activity (O 2 production), GPx activity (GSH depletion)