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FOXO4 D-Retro-Inverso peptide selectively induces apoptosis of senescent cells reverses effects of chemotoxicity and aging in mice

In parallel, neuron counts and synaptophysin (SYP) a synaptic marker increased, astrocyte and microglial activation decreased, and the inflammatory profile shifted favourably: IL-1 and TNF- fell while anti-inflammatory IL-10 rose

Brcic, et al

The idea behind it is genuinely elegant: rather than tweaking brain chemicals the way caffeine or a stimulant does, dihexa was supposed to help neurons physically grow new synapses the connection points where brain cells talk to each other

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