Key studies: 1) Phase 1b mono (Diabetes Care 2021) studied 0.164.5 mg/week 26 weeks, dose-dependent weight loss up to 10.8%
This almost ensures full absorption, which helps people who struggle to get enough B12 from food or pills
Additionally, mast cell activation can occur by IgG-antigen complexes, pathogen-associated molecular patterns (PAMPS), cell-cell contact, and hormones.[ref] Mast cell release exosomes and microRNAs: In addition to degranulating, mast cells also communicate with other cells by secreting mediators and by releasing exosomes
Mild redness, tenderness, or temporary swelling at the injection site may occur
Alternatively, 1000mcg can be given daily SC/IM for 2-7 days, followed by maintenance treatment