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Grant, B.F., et al., Nicotine dependence and psychiatric disorders in the united states: Results from the national epidemiologic survey on alcohol and relatedconditions

Interpretation, Strengths, and Limitations This nationwide study demonstrates that starting smoking at a younger age substantially increases the risk of MI and stroke after statistical adjustment for cumulative smoking exposure, and that early initiation intensifies the cardiovascular harm associated with heavier smoking

Cosio MG, Saetta M, Agusti A (2009) Immunologic aspects of chronic obstructive pulmonary disease