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The drug also acts as a crystal poison at the interface, reducing the tendency of calcium oxalate particles to aggregate

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Biopsies can also be taken from the gut, bladder or skin, where the presence of high or abnormal mast cell numbers can be supportive of a diagnosis of MCAS or mastocytosis

Within 24 h of administering 500 mL of AI, cumulative urinary excretion of AS-IV reached 3.91%, indicating linear pharmacokinetics within a 200500 mL dose range, with no accumulation observed following once-daily administration of AI (Xu et al., 2013)