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Public Health 12 , 90369045 (2015)

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Furthermore, the effect of LA (50mg/kg or 100mg/kg) on healthy animals was evaluated in the preliminary experiment, and no changes of renal morphology and function were found in the healthy mice after oral medications of LA (shown in Supplementary Figure 1)

The mechanical load on joints compounds the inflammatory damage, and most treatments manage symptoms rather than addressing the underlying drivers