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Joseph McClernon, PhD, and Lauren R

Explore This Issue ACEP Now: Vol 43 No 10 October 2024 Toxins The plants major toxic alkaloid is nicotine, which binds to nicotinic acetylcholine receptors (nAChRs), is considered a psychostimulant, can produce analgesia and anxiolytic effects, and stimulates specific reward pathways in the brain at low doses

Most tobacco-related deaths occur in low and middle-income countries, which are often targets of intensive tobacco industry interference and marketing