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Thokozani Chakwanila, 11, left, and Misozi Chakwanila, eight, in the tobacco fields in Kasungu district, Malawi

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Lung-specific Lsm2 knockout (Lsm2 / ) mice were generated by administering AdV5-CMV-Cre-mCMV-copGFP via intratracheal administration to C57BL/6J-Lsm2 em#1(flox)Smoc mice

In male rats (n = 65 per sex per dose group), incidences of hibernoma (tumor of the brown fat) were increased at the mid dose (1 tumor, 5 mg/kg/day, 23 times the MRHD exposure based on AUC) and maximum dose (2 tumors, 15 mg/kg/day, 67 times the MRHD exposure based on AUC)

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