Therapeutically, p53 activation dualistically regulates apoptosis and ferroptosis to suppress PCa growth, but ferroptosis-driven macrophage polarization in the TME may inadvertently promote tumor metastasis [Figure 2A], emphasizing the need for context-specific modulation to balance efficacy and paradoxical outcomes
Airborne Microbes: Dust particles and microorganisms present in the air can settle on exposed surfaces or enter open vials
The molecular gutliver signaling, we substantially revised the manuscript with detailed discussions of key pathways: TLR4/NF-B, MAPK signaling, tight junction regulation, microbial metabolite signaling (e.g., SCFAs), and cytokine cascades
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Schmitt, B., Vicenzi, M., Garrel, C., & Denis, F