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This depigmenting potential can be attributed to the inhibition of tyrosinase transcription and disruption of melanin synthesis (Rendon and Dryer, 2016

Oxidative modification or carbonylation covalently modifies endogenous enzymes and proteins, which can result in the loss of protein function, insulin resistance (IR), and impaired cell function, and play a significant role in the etiology of several human diseases (2, 5, 6, 15, 37, 46, 47)

Mechanism of time-dependent inhibition of 5 alpha-reductase by delta 1-4-azasteroids: Toward perfection of rates of time-dependent inhibition by using ligand-binding energies.Biochemistry1995;34:13453-3459 85

Orphanet J Rare Dis 16:308

This approach helps minimize potential detoxification reactions while allowing the body to adapt to enhanced toxin elimination