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Induction and transcriptional regulation of the co-inhibitory gene module in T cells

doi: 10.1016/j.ijrobp.2021.03.047 342 ZhouHTuCYangPLiJKeppOLiHet al

In the transverse aortic constriction model, PGC-1 deficiency aggravates oxidative stress, decreases cardiac efficiency, glucose metabolism, and hexokinase II protein, further accelerating the transition to HF, while PGC-1 activation mediates the protective roles of melatonin and attenuates cardiac contractile function

This gene encodes the glycolytic enzyme fructose-1,6-bisphosphate aldolase A, which is associated with cancer progression 29,30,31

Moreover, the inhibition of GSH synthesis by buthionine sulphoximine (BSO) sensitized OCCC cells to carboplatin 23