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In contrast, in the ASPREE (a randomized double-blind placebo-controlled trial) trial, daily low-dose aspirin in older adults without known disease did not reduce cardiovascular disease-related mortality and increased bleeding and all-cause mortality (McNeil et al., 2018a

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Peer review Peer review information Communications Biology thanks Irena Mateko-Burmann, Ulf Dettmer and the other anonymous reviewer(s) for their contribution to the peer review of this work

Researchers examining potential neurological or cognitive effects often prefer the nasal route because it provides more direct access to the central nervous system