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Howells DW, Porritt MJ, Wong JY, Batchelor PE, Kalnins R, Hughes AJ et al (2000)

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Lab Invest 99: 514527

What the evidence suggests: dermatological observations have noted skin-brightening effects, particularly in hyperpigmentation, melasma, and post-inflammatory darkening

In PEP-PTS, phosphoenolpyruvate serves as the phosphate donor to the recipient monosaccharide, and PTS internalizes monosaccharide and concomitant phosphorylation