MYC, metabolism, and cancer
EVs have been harnessed as delivery systems for proteins and genetic materials 209
Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)
However, for some Asians, Ashkenazi Jews and others whose gene pool contains a mutant or altered form of the ALDH2 gene, the toxic acetaldehyde isnt broken down as quickly, so it hangs around and accumulates in the liver and body resulting in what is known as the Asian glow
PubMed Central, Yang, Qin, and Guo-Wei He