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If after increasing the dosage, unacceptable opioid-related adverse reactions are observed (including an increase in pain after dosage increase), consider reducing the dosage (see WARNINGS)

Se pueden aplicar productos antiinflamatorios y sedantes para reducirlos

In the heart, histamine increases the force of contraction, and even as far back as 1913, histamine has been known to induce heart arrhythmias.[ref][ref] Mast cells and histamine release: Mast cells are a type of immune cell that creates and stores histamine