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But acknowledged it was difficult to draw concrete conclusions one way or the other about the use of antioxidants for COVID-19

Moreover, our cell-based activity assays showed that the HGF with mutations that disrupt either K1SEMA or SPHSEMA interaction no longer activated c-MET, but the HGF with mutations that disrupt either NSEMA, K2SEMA, or K3SEMA interaction still exhibited partial activity, suggesting that the K1SEMA and SPHSEMA interfaces are more critical for HGF-induced c-MET activation than any other interfaces

These are not cherry-picked responders

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In contrast, the glycoalkaloid fraction alone exhibited toxicity at doses of 200 and 400 mg/kg (515)