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Engineered msc-sevs as a versatile nanoplatform for enhanced osteoarthritis treatment via targeted elimination of senescent chondrocytes and maintenance of cartilage matrix metabolic homeostasis

Alendronate-functionalized nanoparticles target RANKL signaling, reducing osteoclast activity (40)

In addition to these external stresses, there are many intrinsic toxicants produced during physiological metabolism and pathological processes, including reactive oxygen species (ROS) and proinflammatory cytokines

Most cases of premature hair greying stem from factors unrelated to supplementation, such as genetics or lifestyle

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