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There is ongoing debate on the more effective method, with some preferring local injections for direct injury treatment, although systemic administration is also believed to be effective 3 4

Hupalo D, et al

In POF animal models, induced by drugs, radiotherapy, or heavy metals, resveratrol significantly promotes primordial follicle activation, increases the number of primary, primordial, and growing follicles, stimulates GC proliferation, diminishes ovarian inflammation, maintains ovarian architecture, and rescues oocyte and GC apoptosis (Said et al., 2016

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