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Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites

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We could observe a synergistic effect of the combination treatment in NCI-H1975 (CI = 0.58), Calu-6 (CI = 0.64) and NCI-H1299 (CI = 0.42)

Overall, these findings highlight the promising yet preliminary nature of BPC-157 and TB-500 research and reinforce the urgent need for standardized, large-scale clinical trials and robust safety monitoring frameworks before these compounds can be confidently integrated into clinical practice

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