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FAPCAR-T cells generated via the CD5/ LNP-mRNA system IVT (in vitro transcription) mRNA comprised a 5 cap structure, optimized UTR domains, a Kozak sequence, a modified poly(A) tail and an ORF domain encoding the CAR sequence (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] Hausinger R

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The regimen may be changed or stopped if the therapy isnt working by weeks 8 to 12, if the patient has a new medical condition, or if side effects become bothersome