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miRNAs modulate autophagy by directly targeting the mRNAs of ATGs or by regulating the transcription factors essential for controlling autophagy

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Nevertheless, TMZ faces pharmacokinetic challenges, including a short plasma half-life (~2 hours), susceptibility to P-glycoprotein (P-gp) efflux, and limited penetration across the blood-brain barrier (~20%) (70)

Years of research and clinical experience have led me to discover

PMID: 6137189