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This experimentation led to an upregulation of neurogenic differentiation markers, including Nestin, GAP43, Tubulin III, and Doublecortin, in hGMSCs

Beyond lysosomal deacidification and inhibition of autophagosome-lysosome fusion, CQ/HCQ disrupts endolysosomal function, Toll-like receptor activation, and calcium signaling, thereby reducing pro-inflammatory cytokine production

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Sildenafil has shown promising benefits for HAPH patients by blocking the breakdown of NO to promote pulmonary artery vasodilation

However, the brain has a "hybrid engine." The Ketogenic Solution: By adopting a ketogenic diet or utilizing exogenous ketone esters , we provide the brain with Beta-Hydroxybutyrate (BHB)