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doi: 10.1016/S2666-5247(22)00359-7 188 MasonPHSweetlandACFoxGJHalovicSNguyenTAMarksGB

GHK-Cu has been shown to reduce markers of inflammation and oxidative stress in both cell culture and animal models

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Metformins AMPK-dependent actions also extend to cardiopulmonary I/R models, where it reduces oxidative stress, suppresses inflammatory cytokines (TNF-, IL-1), and inhibits NF-B signaling, collectively preserving tissue integrity (Liu et al., 2024)