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The mitochondrial origin means MOTS-c acts at the cellular energy level in a way no GHRH analog, tissue-repair peptide, or cognitive peptide does

The presence of tumor stem cells is directly correlated with chemotherapy resistance in HGSOC, and these cells can evade drug effects through multiple mechanisms ( In our comprehensive exploration of HGSOC drug resistance mechanisms, we identified a complex and diverse biological foundation involving abnormalities in multiple cellular signaling pathways and alterations in the tumor microenvironment