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Notably, the relative contribution of M2 macrophages to osteogenesis remains controversial across different pathological contexts, including diabetic osteoporosis, aging-related bone loss, and postmenopausal fractures

However, a significant decrease in cell viability was observed for the solutions with pH lower than 2.5

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These proteases include cell surface transmembrane protease/serine (TMPRSS) proteases, cathepsins , furin, elastase, factor Xa, and trypsin 70

Simoes et al., 2019)