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Key factors include enhanced renal iodine clearance, elevated placental thyroid hormone deiodination, and estrogen-mediated increases in thyroid-binding globulin with corresponding decreases in free thyroid hormones

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Moreover, heavy metals can deplete glutathione, a master intracellular antioxidant, by binding to thiol groups or interfering with glutathione synthesis and recycling (Ercal et al., 2001

GR (EC 1.6.4.2) activity was determined as NADPH oxidation recorded at 340 nm [26]